Chemical Safety Science, 2017, Volume 1, No 1, p. 193 — 199

 

Chemical hazard sources. Hazardous chemical substances

 

UDC 615.9:632.95(476)                                                                    Download PDF (RUS)

DOI: 10.25514/CHS.2017.1.11444

 

STUDY OF TOXICOLOGICAL AND HYGIENIC CHARACTERISTICS OF PLANT PROTECTION AGENT

S. Yu. Petrova*, T. N. Gomolko, and O. A. Boris

Republican Unitary Enterprise “Scientific and Practical Center of Hygiene”, Minsk, Republic of Belarus

Received April 20, 2017

Published June 26, 2017

 Abstract – The results are presented referring to studying toxicological and hygienic characteristics of a chemical agent for plant protection – VIAL Trio, disinfectant. The agent represents an aqueous suspension of concentrated composition involving three fungicides, i.e. prochloraz, thiabendazole, and cyproconazole. The research has been carried out taking into account the principles of identification and classification of hazardous chemical production. Acute toxicity experiments with single dose intestinal and dermal routes of administration have shown that the agent can be classified as a low-risk substance (hazard class 4). The results of testing agent’s skin irritant action and its irritant action on eye membrane sensibility of laboratory animals have revealed that the agent refers to substances that do not irritate skin and have moderate irritant effect on mucous membranes; also the agent does not exhibit a cumulative effect and has no sensitizing effect in mouse paw edema test.

Keywords: toxicity, average lethal dose (LD₅₀), cumulative properties, irritant action, skin irritant effect, sensitizing effect.