Chemical Safety Science, 2018, Volume 2, No 2, p. 85 — 95


Chemical hazard sources. Hazardous chemical substances


UDC: 615.91                                                                                   Download PDF (RUS)

DOI: 10.25514/CHS.2018.2.14105



V. S. Roumak1,2, E. S. Levenkova*1,2, and N. V. Umnova1

1Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, Russia

2Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

Received October 09, 2018

Published December 26, 2018

Abstract – The data obtained by the authors in their own long-term investigations of an ecologically-dependent pathology emerged among the population of Vietnam as a result of applying dioxin-contaminated Agent Orange by the US Army between 1962 and 1971, were systematized and used for addressing a problem of low dose toxicometry of dioxins and their prolonged chronic effects on mammals and humans. The prospects for extending the above scientific research data to public health hazards in Russia were demonstrated in screening evaluation study of an ecotoxicological situation observed in the residential areas located in the vicinity of a municipal solid waste landfill (Salariyevo, New Moscow). These data provide a basis for creating a new approach for identifying disadvantaged areas polluted with dioxins. The scientific relevance of the studies is consistent with a task of overcoming the so-termed big challenges taken as strategic guidelines for scientific and technological development of the Russian Federation.

Keywords: dioxins, superecotoxicants, ecology-dependent pathology, dioxin pathology, large challenges, screening evaluation.


1. Kuntsevich A.D. // Uspekhi khimii [Advances in Chemistry]. 1991. V. 60. No. 3. P. 530 [in Russian].
2. The Stockholm Convention on Persistent Organic Pollutants. (accessed 9.10.2018).
3. Federal Target Program “Protection of the Environment and the Population from Dioxins and Dioxin-Like Toxicants for 1996-1997” [in Russian].
4. Klyuev N.A., Kurlyand B.A., Revich B.A., Filatov B.N. Dioxins in Russia. M.: UNEP, 2001. 212 p. [in Russian].
5. Agapkina G.I., Brodsky E.S., Shelepchikov A.A. et al. // Vestnik Moskovskogo Universiteta [Moscow University Bulletin]. Ser. 17. Soil Science. 2010. No. 3. P. 16 [in Russian].
6. Birnbaum L.S. // Environ. Health Perspectives. 1994. V. 102. No. 8. P. 676.
7. Birnbaum L.S., Tuomisto J. // Food Addit. Contam. 2000. V. 17. No. 4. P. 275.
8. Tavakoly Sany S.B., Hashim R., Salleh A. et al. // Environ. Sci. Pollut. Res. 2015. V. 22. P. 19434. doi: 10.1007 / s11356-015-5597-x.
9. Krishtopenko S.V., Tikhov M.S., Popova E.B. Paradoxical toxicity. Nizhny Novgorod: Izd. Nizhny Novgorod State Medical Academy, 2001. P. 28 [in Russian].
10. Poznyakov S.P., Roumak V.S., Sofronov G.A., Umnova N.V. Dioxins and Human Health: The Scientific Basis for the Detection of Dioxin Pathology. SPb.: Science, 2006. 274 p. [in Russian].
11. Roumak V.S., Umnova N.V., Levenkova E.S. et al. // Ekologiya cheloveka [Human Ecology]. 2017. No. 10. P. 9 [in Russian].
12. The remote biological consequences of the war in southern Vietnam. Ed. by V.E. Sokolov, S.A. Shilova. M., 1996. P. 17 [in Russian].
13. Fokin A.V., Kolomiets A.F. // Priroda [Nature]. 1985. No. 3. P. 3 [in Russian].
14. Westing A.H. Herbicides in War: The Long-term Ecological and Human Consequences. London, England: Taylor & Francis, 1984. P. 1.
15. Environment and human health in dioxin-polluted regions of Vietnam. M.: Tovarishchestvo nauchnykh izdaniy KMK [Partnership of scientific publications KMK]. 2011. 271 p. [in Russian].
16. Roumak V.S., Umnova N.V., Sofronov G.A., Pavlov D.S. Molecular toxicology of dioxins. SPb.: Nauka, 2013. 63 p. [in Russian].
17. Roumak V.S., Umnova N.V., Sofronov G.A. // Vestnik RAMN [Bulletin of the Russian Academy of Medical Sciences]. 2014. No. 3-4. P. 77 [in Russian].
18. Sofronov G.A., Roumak V.S., Umnova N.V. et al. // Med. academich. Zhurnal [Medical Academic Journal]. 2016. V. 16. No. 3. P. 7 [in Russian].
19. Hygienic Standard “Approximate permissible concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (equivalent to 2,3,7,8-tetrachlorodibenzopara-dioxin and its analogues) in the soil of populated areas, agricultural lands and industrial site”. September 15, 2015 (accessed 9.10.2018) [in Russian].
20. Sycheva L.P., Umnova N.V., Kovalenko M.A. et al. // Chemosphere. 2016. V. 144. P. 1415.
21. Roumak V.S., Umnova N.V., Belov D.A., Lazareno D.Yu. Studies of the links between the levels of PCDD/ PCDFs in the environment, in the organisms of rural Vietnamese population and their diagnosable health characteristics. In: Environment and human health in dioxin-polluted regions of Vietnam. M.: Tovarishchestvo nauchnykh izdaniy KMK, 2011. P. 186 [in Russian].
22. Umnova N.V., Zhuchenko N.A., Lazarenko D.Yu. et al. Ecological and genetic studies of the health of post-war generations in the provinces of QuangChi and BinZyong. In: Environment and human health in dioxin-polluted regions of Vietnam. M.: Tovarishchestvo nauchnykh izdaniy KMK, 2011. P. 130 [in Russian].
23. Nishijo M., Pham T.T., Nguyen A.T. et al. // Mol. Psychiatry. 2014. V. 19. No. 11. P. 1220.
24. Suzuki H., Kido T., Okamoto R. et al. // int. J. Mol. Sci. 2014. V. 15. No. 5. P. 7485.
25. Tai P.T., Nishijo M., Anh N.T. et al. // Occup. Environ. Med. 2013. V. 70. No. 9. P. 656.
26. Zhuchenko N.A., Umnova N.V., Roumak V.S. et al. // Vestnik RAMN [Bulletin of the Russian Academy of Medical Sciences]. 2006. No. 7. P. 3 [in Russian].
27. Ostashevsky V.A., Gerasimov K.E., Tsyrlov I.B. et al. // Izvestiya RAN. Ser. Biol. [Biology Bulletin]. 1994. No. 1. P. 56 [in Russian].
28. Umnova N.V., Roumak V.S., Hoang Anh Tuet, Sofronov G.A. Ecological and genetic manifestations of the remote medical consequences of the use of military phytotoxicants in Vietnam. Dioxins. Superecotoxicants of XXI century. Inf. issue No. 8. M.: VINITI, 2003. P. 85 [in Russian].
29. Guidelines for assessing the risk to public health upon exposure of chemicals polluting the environment. Guide. R M., 2004 [in Russian].